González Martínez, Antonio Javier
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- PublicaciónCalibration of Gamma Ray Impacts in Monolithic-Based Detectors Using Voronoi Diagrams(Institute of Electrical and Electronics Engineers, 2020-05) Freire, Marta; Gonzalez-Montoro, Andrea; Sánchez Martínez, Filomeno; Benlloch Baviera, Jose María; González Martínez, Antonio Javier; Instituto de Instrumentación para Imagen Molecular; European Commission; Ministerio de Economía y Competitividad[EN] Molecular imaging systems, such as positron emission tomography (PET), use detectors providing energy and a 3-D interaction position of a gamma ray within a scintillation block. Monolithic crystals are becoming an alternative to crystal arrays in PET. However, calibration processes are required to correct for nonuniformities, mainly produced by the truncation of the scintillation light distribution at the edges. We propose a calibration method based on the Voronoi diagrams. We have used $50 \times 50 \times 15$ mm(3) LYSO blocks coupled to a $12\times 12$ SiPMs array. We have first studied two different interpolation algorithms: 1) weighted average method (WAM) and 2) natural neighbor (NN). We have compared them with an existing calibration based on 1-D monomials. Here, the crystal was laterally black painted and a retroreflector (RR) layer added to the entrance face. The NN exhibited the best results in terms of XY impact position, depth of Interaction, and energy, allowing us to calibrate the whole scintillation volume. Later, the NN interpolation has been tested against different crystal surface treatments, allowing always to correct edge effects. Best energy resolutions were observed when using the reflective layers (12%-14%). However, better linearity was observed with the treatments using black paint. In particular, we obtained the best overall performance when lateral black paint is combined with the RR.
- PublicaciónDevelopments in Dedicated Prostate PET Instrumentation(2024-01) González Martínez, Antonio Javier; González-Montoro, Andrea; Instituto de Instrumentación para Imagen Molecular; Generalitat Valenciana[EN] Some specific MI designs assessing early detection and staging of PCa have been proposed. It can be differentiated between systems (dedicated-, WB-and TB-PET), and inserts or probes that are placed much closer to the prostate with the aim to boost spatial resolution (magnification effect) and eventually sensitivity in the area under observation. Fully prostate-dedicated systems have not yet reached an optimum of performance to be transferred to the clinics or industry, most likely due to the lack of precise detectors able to include DOI and TOF capabilities simultaneously at an affordable cost. Moreover, several attempts have been carried out in a variety of probe technologies such as PET alone, US combined, with TOF capabilities and even MRI compatible, reporting promising results.It seems very likely that using images provided by prostate dedicated-PET scanners for biopsy guidance would help in diagnosis. As reviewed in the present article, this may be accomplished with dedicated prostate PET using for instance TransRectal PET imaging probes resulting in a high sensitivity.As an alternative to dedicated PET and the combination PET probe, currently available PET scanners could be technologically upgraded by designing more precise detectors or/and by including AI techniques. To accomplish these goals, advancements in the detection technology are required. There have been several encouraging attempts during the last years on these lines, and it seems feasible that enhanced PET and TB PET technology may become a reality soon, and thus, their use could be extended for PCa.