González Martínez, Antonio Javier
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- PublicaciónPETIROC2 based readout electronics optimization for Gamma Cameras and PET detectors(IOP Publishing, 2017) Monzó Ferrer, José María; Aguilar -Talens, Albert; González Montoro, Andrea; Lamprou,E.; González Martínez, Antonio Javier; Hernández Hernández, Liczandro; Mázur, Dmytro; Colom Palero, Ricardo José; Benlloch Baviera, Jose María; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Instituto de Instrumentación para Imagen Molecular; Ministerio de Economía, Industria y Competitividad[EN] Developing front-end electronics to improve charge detection and time resolution in gamma-ray detectors is one of the main tasks to improve performance in new multimodal imaging systems that merge information of Magnetic Resonance Imaging and Gamma Camera or PET tomographs. The aim of this work is to study the behaviour and to optimize the performance of an ASIC for PET and Gamma Camera applications based on SiPMs detectors. PETIROC2 is a commercial ASIC developed by Weeroc to provide accurate charge and time coincidence resolutions. It has 32 analog input channels that are independently managed. Each channel is divided into two signals, one for time stamping using a TDC and another for charge measurement. In this work, PETIROC2 is evaluated in an experimental setup composed of two pixelated LYSO crystals based detectors, each coupled to a Hamamatsu 4 x 4 SiPM array. Both detectors are working in coincidence with a separation distance between them that can be modified. In the present work, an energy resolution of 13 : 6% FWHM and a time coincidence resolution of 815 ps FWHM have been obtained. These results will be useful to optimize and improve PETIROC2 based PET and Gamma Camera systems.
- PublicaciónPET detector block with accurate 4D capabilities(Elsevier, 2018-12-21) Lamprou, Efthymios; Aguilar -Talens, Albert; Gonzalez-Montoro, Andrea; Monzó Ferrer, José María; Cañizares-Ledo, Gabriel; Iranzo-Egea, Sofía; Vidal San Sebastián, Luis Fernando; Hernández Hernández, Liczandro; Conde-Castellanos, Pablo Eloy; Sánchez-Góez, Sebastián; Sánchez Martínez, Filomeno; González Martínez, Antonio Javier; Benlloch Baviera, Jose María; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Instituto de Instrumentación para Imagen Molecular; European Commission; Ministerio de Economía y Competitividad[EN] In this contribution, large SiPM arrays (8 x 8 elements of 6 x 6 mm(2) each) are processed with an ASIC-based readout and coupled to a monolithic LYSO crystal to explore their potential use for TOF-PET applications. The aim of this work is to study the integration of this technology in the development of clinical PET systems reaching sub-300 ps coincidence resolving time (CRT). The SiPM and readout electronics have been evaluated first, using a small size 1.6 mm (6 mm height) crystal array (32 x 32 elements). All pixels were well resolved and they exhibited an energy resolution of about 20% (using Time-over-Threshold methods) for the 511 keV photons. Several parameters have been scanned to achieve the optimum readout system performance, obtaining a CRT as good as 330 +/- 5 ps FWHM. When using a black-painted monolithic block, the spatial resolution was measured to be on average 2.6 +/- 0.5 mm, without correcting for the source size. Energy resolution appears to be slightly above 20%. CRT measurements with the monolithic crystal detector were also carried out. Preliminary results as well as calibration methods specifically designed to improve timing performance, are being analyzed in the present manuscript.
- PublicaciónMetascintillators: New Results for TOF-PET Applications(Institute of Electrical and Electronics Engineers, 2022-05) Lecoq, Paul; Konstantinou, Georgios; Latella, Riccardo; Moliner Martínez, Laura; Nuyts, Johan; Zhang, Lei; Barrio Toala, John; Benlloch Baviera, Jose María; González Martínez, Antonio Javier; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Instituto de Instrumentación para Imagen Molecular; European Commission; European Research Council[EN] We report on the progress on a first generation of realistic size metascintillators for time-of-flight PET. These heterostructures combine dense LYSO or BGO plates, interleaved with fast scintillator layers producing a bunch of prompt photons from the energy leakage of the recoil photoelectric electron. From a Geant4 simulation of the energy sharing distribution between the dense and the fast scintillator on 42 LYSO-based and 42 BGO-based configurations, a detailed study of the timing performance has been performed on a selection of the most promising 12 LYSO-based and 14 BGO-based metascintillators. A Monte Carlo simulation was first performed to extrapolate from direct measurements of the performance of the metascintillator components, the detector time resolution (DTR), and sensitivity on the basis of the simulated amount of energy leakage to the fast scintillator. An analytic algorithm was then applied to determine an equivalent coincidence time resolution (CTR) from the random association of the DTR distributions from two metapixels in coincidence. This equivalent CTR is calculated in order to obtain the same variance in the reconstructed image as the combination of the DTR distributions of 2 metapixels. Preliminary results confirm that with these simple and still nonoptimized configurations, an equivalent CTR of 150 ps for BGO-based and 140 ps for LYSO-based metapixels of realistic size can be obtained
- PublicaciónScanner calibration of a small animal PET camera based on continuous LSO crystals and flat panel PSPMTs(Elsevier, 2007-02-01) Benlloch Baviera, Jose María; Carrilero, V.; González Martínez, Antonio Javier; Catret, J.; Lerche, Christoph Werner; Abellan, D.; García de Quiros, F.; Gimenez, M.; Modia, J.; Sánchez, Filomeno; Ros García, Ana; Martínez, J.; Sebastia Cortes, Angel; Instituto de Instrumentación para Imagen Molecular[EN] We have constructed a small animal PET with four identical detector modules, each consisting of a continuous LYSO crystal attached to a Position Sensitive Photomultiplier Tube (PSPMT). The dimensions of the continuous crystal are 50 x 50 mm 2 and 10 mm thickness. The modules are separated 11 cm between each other in the scanner. In this paper we discuss the method used for the calibration of the camera for this special system with continuous detectors. We also present the preliminary values for the main performance parameters such as spatial and energy resolution, and sensitivity of the system. (c) 2006 Elsevier B.V. All rights reserved.
- PublicaciónProgrammable integrated front-end for SiPM/PMT PET detectors with continuous scintillating crystal(IOP Publishing: Hybrid Open Access, 2012-12) Herrero Bosch, Vicente; Monzó Ferrer, José María; Ros García, Ana; Aliaga Varea, Ramón José; González Martínez, Antonio Javier; Montoliu, C.; Colom Palero, Ricardo José; Benlloch Baviera, Jose María; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Instituto Universitario de Matemática Pura y Aplicada; Instituto de Instrumentación para Imagen Molecular; Universitat Politècnica de València[EN] AMIC architecture has been introduced in previous works in order to provide a generic and expandable solution for implementing large number of outputs SiPM array/PMT detectors. The underlying idea in AMIC architecture is to calculate the moments of the detected light distribution in an analog fashion. These moments provide information about energy, x/y position, etc. of the light distribution of the detected event. Moreover this means that a small set of signals contains most of the information of the event, thus reducing the number of channels to be acquired. This paper introduces a new front-end device AMIC2GR which implements the AMIC architecture improving the features of the former integrated devices. Higher bandwidth and filtering coefficient precision along with a lower noise allow to apply some detector enhancements. Inhomogeneity among detector elements throughout the array can be reduced. Depth of interaction measurements can be obtained from the light distribution analysis. Also a common trigger signal can be obtained for the whole detector array. Finally AMIC2GR preamplifier stage close to SiPM output signals optimizes signal to noise ratio, which allows to reduce SiPM gain by using lower operating voltages thus reducing dark noise
- PublicaciónA new brain dedicated PET scanner with 4D detector information(Walter de Gruyter GmbH, 2022-12) González-Montoro, Andrea; Barbera Ballester, Julio; Sánchez Gonzalo, David; Mondejar, Álvaro; Freire-López-Fando, Marta; Díaz González, Karel; Lucero-Ruiz, Alejandro; Jiménez Serrano, Santiago; Alamo Valenzuela, Jorge; Morera Ballester, Constantino; Barrio Toala, John; Cucarella, Neus; Ilisie, Victor; Moliner Martínez, Laura; Valladares de-Francisco, Celia; González Martínez, Antonio Javier; John Prior; Benlloch Baviera, Jose María; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Departamento de Sistemas Informáticos y Computación; Escuela Técnica Superior de Ingeniería Informática; Instituto de Instrumentación para Imagen Molecular; Generalitat Valenciana; European Research Council[EN] In this article, we present the geometrical design and preliminary results of a high sensitivity organ-specific Positron Emission Tomography (PET) system dedicated to the study of the human brain. The system, called 4D-PET, will allow accurate imaging of brain studies due to its expected high sensitivity, high 3D spatial resolution and, by including precise photon time of flight (TOF) information, a boosted signal-to-noise ratio (SNR). The 4D-PET system incorporates an innovative detector design based on crystal slabs (semi-monolithic) that enables accurate 3D photon impact positioning (including photon Depth of Interaction (DOI) measurement), while providing a precise determination of the photon arrival time to the detector. The detector includes a novel readout system that reduces the number of detector signals in a ratio of 4:1 thus, alleviating complexity and cost. The analog output signals are fed to the TOFPET2 ASIC (PETsys) for scalability purposes. The present manuscript reports the evaluation of the 4D-PET detector, achieving best values 3D resolution values of <1.6 mm (pixelated axis), 2.7±0.5 mm (monolithic axis) and 3.4±1.1 (DOI axis) mm; 359 ± 7 ps coincidence time resolution (CTR); 10.2±1.5 % energy resolution; and sensitivity of 16.2% at the center of the scanner (simulated). Moreover, a comprehensive description of the 4D-PET architecture (that includes 320 detectors), some pictures of its mechanical assembly, and simulations on the expected image quality are provided.
- PublicaciónDiseño y primeros resultados de una cámara PET para animales pequeños basada en cristales LYSO continuos y fotomulplicadores sensibles a la posición(Sociedad Española de Física Médica, 2007) Benlloch Baviera, Jose María; González Martínez, Antonio Javier; Carrilero, V.; Catret, J. V.; Correcher, C.; Lerche, Christoph Werner; Morera, C.; Orero, A.; Pavón, N.; Ros García, Ana; Sánchez, F.; Soriano Asensi, Antonio; Vidal San Sebastián, Luis Fernando; Colom Palero, Ricardo José; Gadea Gironés, Rafael; Herrero Bosch, Vicente; Mora, C.; Mora Mas, Francisco José; Sebastia Cortes, Angel; Munar, A.; Departamento de Ingeniería Electrónica; Escuela Técnica Superior de Ingeniería de Telecomunicación; Instituto de Instrumentación para Imagen Molecular[ES] En este artículo presentamos el diseño de un nuevo escáner PET para animales pequeños basado en una tecnología completamente innovadora. Los resultados preliminares son muy prometedores, permitiendo obtener imágenes funcionales de alta resolución con una instrumentación compacta y de bajo coste. Los prototipos desarrollados se encuentran actualmente en pruebas en diversos centros de investigación médica, obteniéndose imá- genes de alta calidad en los campos de oncología, neurología y cardiología. Este diseño puede ser fácilmente extendido a cámaras PET dedicadas a la exploración del cerebro o de la mama. La innovación más notable de la presente tecnología consiste en el uso de un único cristal continuo por módulo, a diferencia de otras cámaras PET comerciales donde se utilizan cientos de cristales pixelados. El uso de un único cristal continuo permite abaratar el coste de fabricación, al tiempo que mejora las características de funcionamiento: resolución intrínseca en posición de 1,2 mm, resolución en energía media del 14%, resolución en la profundidad de interacción de 3 mm, sensibilidad > 4% y campo de visión transaxial de 80 mm de diámetro. En el presente artículo se describen en detalle el diseño de esta nueva cámara PET, los principios de funcionamiento, el método utilizado para su calibración y se anticipan algunas imágenes "in vivo" del miocardio y el cerebro de un ratón, permitiendo apreciar de forma preliminar la resolución y calidad alcanzadas.